Twilight Sparkle (Sci-Twi)

Twilight Sparkle 's human counterpart is a student at Canterlot High School, a former student at Crystal Prep Academy, and the owner of Spike. This version of Twilight looks extremely different from Equestria's Twilight as she has her hair in a bun and wears thick black glasses, similar to the look pony Twilight dons when she plays a therapist to Rainbow Dash in Lesson Zero. She is called Sci-Twi in some other depictions.

My Little Pony Equestria Girls: Rainbow Rocks
After the credits roll, Twilight Sparkle pieces together some strange events that occurred at Canterlot High School. She talks to her dog Spike.

My Little Pony Equestria Girls: Friendship Games
In the third Equestria Girls film, Twilight's human counterpart is revealed to be attending Crystal Prep Academy and is a member of the Wondercolts' rival, the Shadowbolts. This version of Twilight is portrayed as being rather awkward and curious.

Throughout the film, Twilight attempts to track and measure strange energy readings at Canterlot High, recording all of her findings on a tack board in a secret room at Crystal Prep. She gathers this research in hopes of being accepted into an independent study program, and she only competes with the Shadowbolts to do further observations of the weird energy.

Twilight carries a device intended to detect the strange readings. However, it also drains magic away, causing each of the Rainbooms to lose their ability to pony up. In addition, it causes dimensional rifts to appear throughout the Games. When Principal Cinch discovers this, she pressures Twilight to release the magic from her device to win the Games. Once she does, the magic engulfs her, and she transforms into a monstrous creature obsessed with magic. After her transformation, Twilight uses her powers to open additional rifts to Equestria. Using Twilight's device, Sunset channels the released magic to transform herself. Following an explosive battle, Sunset offers Twilight her hand in friendship, and Twilight accepts. Twilight apologizes for all the trouble she caused, and Sunset and her friends forgive her.

Later, Twilight decides to forego her independent study application and transfer to Canterlot High to learn about the magic of friendship.

Friendship Games description
''Meet Crystal Prep Twilight Sparkle, the Twilight Sparkle who has always lived in Equestria Girls world – she just goes to another school! You'll recognize this Twilight Sparkle by her signature glasses. She maintains the same personality traits of the Twilight we know from the MLP world, but she has yet to learn about the magic of friendship''